Black Women are Being Left Out of Advancements in Genetic Medicine
Researchers from the Duke University School of Medicine examined the HPV subtypes present in 572 people who were part of the Cervical Intraepithelial Neoplasia Cohort Study, all of whom had abnormal Pap tests. Of those women, 280 were African American and 292 were white. They looked particularly at HPV subtypes present in the women’s cervical intraepithelial neoplasias (CIN), which are abnormalities in the cervix that are considered precursors to cervical cancer. They wanted to see what differences there may be in early CIN (called CIN1) and more advanced CIN (called CIN2 and CIN3).
“These are young women in the prime of their careers, family and fertility. This means a severely compromised future with a disease that waxes and wanes, affecting every aspect of daily living for the rest of their lives.” Among the women with early CIN, HPV subtypes 16, 18, 31, 56 39 and 66 were the most frequently detected among white women. For African American women, though, the HPV subtypes 33, 35, 58 and 68 were most frequently detected.
I lost one of dear friends in college to Lupus. It was not a rarity, black women had very high rates of lupus, with an incidence rate in Georgia nearly three times higher than that for white women, with significantly high rates in the 30-39 age group,” says principal investigator, S. Sam Lim, MD, MPH, associate professor in the Division of Rheumatology at Emory University School of Medicine.
There are substantial racial disparities in the burden of lupus, according to initial data from the largest and most far-reaching study ever conducted on the disease and published online today by the journal, Arthritis and Rheumatism. The data confirms that black females disproportionately are burdened by lupus, a devastating and complicated autoimmune disease. “These are young women in the prime of their careers, family and fertility. This means a severely compromised future with a disease that waxes and wanes, affecting every aspect of daily living for the rest of their lives.”
Black women with breast cancer are more likely than women in the general population to have genetic mutations linked to their disease, and a significant proportion of those mutations extend beyond the common BRCA1 and BRCA2 mutations, a new study has found.
In the first comprehensive analysis of all known breast cancer susceptibility genes in a black cohort, mutations were most prevalent in women with early-onset disease, triple-negative disease, or a family history of breast, ovarian, or pancreatic cancer. The findings suggest that broader genetic screening than is currently clinically available might be warranted in high-risk black patients and their families, said study author Jane Churpek, MD, a hemotologist/oncologist at the University of Chicago.